Lipoproteins are spherical-shapedparticles that contain varying amounts of cholesterol, triglycerides,phospholipids and proteins. The relative amounts of the protein and lipidconstituents determine the density of the lipoprotein particles. The studiesall point to low-density lipoprotein (LDL) cholesterol as the key factor in thepathogenesis of artherosclerosis and coronary artery disease (CAD). Even withinthe normal range of total cholesterol concentrations, an increase in LDLcholesterol can occur with an
associated risk for CAD.